The Role of High-Power Pulsed Laser Therapy in Treating

Neuro-musculoskeletal Disorders

High Power-Pulsed Laser Therapy (HPPLT) is classified as an actinotherapy meaning it results in a chemical and metabolic change in living tissue – this is called photo-biomodulation.

HPPLT can facilitate the healing and regeneration of living tissue. HPPLT has been shown to inhibit scar tissue formation, at the same time, stimulating collagen, elastin, and fibrocartilage growth. As a result, most tissues heal twice as strong as natural healing due to the lack of non-functional adhesions and scar tissue formation.

HPPLT can also heal disc pathology. The outer 1/3 of the intervertebral disc is vascularized, HPPLT can stimulate neo-capillary growth and fibroblast proliferation causing the disc to become more elastic and resilient. No other therapy or modality can achieve these desired effects.

Additionally, HPPLT activates stem cells, as well as osteoblasts in the bone. Fractures heal in half the time with less chance of non-union.

Today, High Power Pulsed Laser Therapy is considered the best and safest treatment available for nerve pathology. Photo-modulation with HPPLT causes increased intraneural blood flow and accelerated peripheral nerve regeneration – this translates into decreased numbness, tingling, pain, and balance disturbances.

Reference Materials

Below is a list of pertinent medical literature supporting the use of laser therapy to treat neuro-musculoskeletal disorders:

1) Lasers Med Sci. 2015 Dec;30(9):2335-9. doi: 10.1007/s10103-015-1814-6. Epub 2015 Sep 29. Does the addition of low-level laser therapy (LLLT) in the conservative care of knee arthritis successfully postpone the need for joint replacement? Ip D1.

2) J Lasers Med Sci. 2014 Autumn; 5(4): 163–170. PMCID: PMC4281990 PMID: 25653816. Effect of Low-Level Laser Therapy on Proliferation and Differentiation of the Cells Contributing to Bone Regeneration. Reza Amid, 1 Mahdi Kadkhodazadeh, 2 Mitra Ghazizadeh Ahsaie, 3 and Arian Hakakzadeh .3  1 Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran3 Gifted and Talented Dental Students Division, Students’ Research Committee, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Corresponding Author: Mitra Ghazizadeh Ahsaie, DDS; Gifted and Talented Dental Students Division, Students’ research committee, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Copyright © 2014 J Lasers Med Sci.

3) Lasers Med Sci. 2015 Nov;30(8):2189-94. doi: 10.1007/s10103-015-1730-9. Epub 2015 Mar 13. Effect of low-level laser therapy on mesenchymal stem cell proliferation: a systematic review. Ginani F1, Soares DM2, Barreto MP3, Barboza CA4,5.

4) Pain Res Manag. 2016;2016:9163618. doi: 10.1155/2016/9163618. Epub 2016 Dec 20. Effectiveness of High-Intensity Laser Therapy for Reduction of Pain in Knee Osteoarthritis. Angelova A1, Ilieva EM1

5) Medicine (Baltimore). 2016 Aug;95(31):e4424. doi: 10.1097/MD.0000000000004424. Effectiveness of low-level laser on carpal tunnel syndrome: A meta-analysis of previously reported randomized trials.Li ZJ1, Wang Y, Zhang HF, Ma XL, Tian P, Huang Y

6) J Back Musculoskelet Rehabil. 2018 Feb 6;31(1):191-196. doi: 10.3233/BMR-170793. Efficacy of high-intensity laser therapy in the treatment of patients with lumbar disc protrusion: A randomized controlled trial. Chen L1,1, Liu D1,1, Zou L1, Huang J1, Chen J1, Zou Y1, Lai J1, Chen J1, Li H1, Liu G1.

7) Am J Phys Med Rehabil. 2017 Jun;96(6):e97-e110. doi: 10.1097/PHM.0000000000000675. Efficacy of Stellate Ganglion Blockade Applied with Light Irradiation: A Systemic Review and Meta-analysis. Liao CD1, Tsauo JY, Chen HC, Liou TH.

8) Appl Biochem Biotechnol. 2018 Sep;186(1):161-173. doi: 10.1007/s12010-018-2729-z. Epub 2018 Mar 12. Efficiencies of Low-Level Laser Therapy (LLLT) and Gabapentin in the Management of Peripheral Neuropathy: Diabetic Neuropathy. Abdel-Wahhab KG1, Daoud EM2, El Gendy A2, Mourad HH3, Mannaa FA3, Saber MM2

9) Sci Transl Med. 2014 May 28;6(238):238ra69. doi: 10.1126/scitranslmed.3008234. Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Arany PR1, Cho A2, Hunt TD3, Sidhu G3, Shin K4, Hahm E3, Huang GX3, Weaver J5, Chen AC6, Padwa BL7, Hamblin MR8, Barcellos-Hoff MH9, Kulkarni AB2, J Mooney D10

10) Lasers Surg Med. 2011 Jul;43(5):401-9. doi: 10.1002/lsm.21063. Induction of autologous mesenchymal stem cells in the bone marrow by low-level laser therapy has profound beneficial effects on the infarcted rat heart. Tuby H1, Maltz L, Oron U

11) J Transl Med. 2010; 8: 16. PMCID: PMC2830167 Published online 2010 Feb 16. doi:   [10.1186/1479-5876-8-16] PMID: 20158898 Lasers, Stem Cells, and COPD. Feng Lin,#1 Steven F Josephs,#1 Doru T Alexandrescu,#2 Famela Ramos,1 Vladimir Bogin,3 Vincent Gammill,4 Constantin A Dasanu,5 Rosalia De Necochea-Campion,6 Amit N Patel,7 Ewa Carrier,6 and David R Koos 1

12) Laser Light – A New, Non-invasive Treatment for Erectile Dysfunction: A Placebo-controlled, Single Blinded Pilot Study: Y. Yacobi M.D., A. Sidi M..D. Department of Urologic Surgery, The Wolfson Medical Center, Holon, Israel

13) Stem Cells International Volume 2015, Article ID 974864, 12 pages http://dx.doi.org/10.1155/2015/974864 Review Article Low Reactive Level Laser Therapy for Mesenchymal Stromal Cells Terapies Toshihiro Kushibiki, Takeshi Hirasawa, Shinpei Okawa, and Miya Ishihara
Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. Received 19 September 2014; Accepted 14 March 2015

14) Pain Med. 2010 Aug;11(8):1169-78. doi: 10.1111/j.1526-4637.2010.00907.x. Low-level laser therapy for acute neck pain with radiculopathy: a double-blind placebo-controlled randomized study. Konstantinovic LM1, Cutovic MR, Milovanovic AN, Jovic SJ, Dragin AS, Letic MDj, Miler VMPhotomed Laser Surg. 2016 Dec;34(12):638-645. doi: 10.1089/pho.2016.4095.

15) Photo-biomodulation Triple Treatment in Peripheral Nerve Injury: Nerve and Muscle Response.  Mandelbaum-Livnat MM1, Almog M1, Nissan M1, Loeb E2, Shapira Y1, Rochkind S1

16) Lasers Surg Med. 2016 Jul;48(5):498-504. doi: 10.1002/lsm.22480. Epub 2016 Feb 2. Positive effects of low level laser therapy (LLLT) on Bouchard’s and Heberden’s osteoarthritis. Baltzer AW1, Ostapczuk MS2,3, Stosch D1

17) Lasers Med Sci. 2014 Sep;29(5):1695-700. doi: 10.1007/s10103-014-1576-6. Epub 2014 Apr 15. The effect of low-level laser therapy on knee osteoarthritis: prospective, descriptive study. Soleimanpour H1, Gahramani K, Taheri R, Golzari SE, Safari S, Esfanjani RM, Iranpour A

18) J Lasers Med Sci. 2018 Winter;9(1):63-68. doi: 10.15171/jlms.2018.13. Epub 2017 Dec 26. Therapeutic and Analgesic Efficacy of Laser in Conjunction With Pharmaceutical Therapy for Trigeminal Neuralgia. Ebrahimi H1, Najafi S2, Khayamzadeh M2, Zahedi A3, Mahdavi A4

19) Front Syst Neurosci. 2014; 8: 36. Published online 2014 Mar 14. doi: [10.3389/fnsys.2014.00036] PMCID: PMC3953713 PMID: 24672439 Augmentation of cognitive brain functions with transcranial lasers. F. Gonzalez-Lima* and Douglas W. Barrett

20) AJR Am J Roentgenol. 2017 Feb;208(2):380-385. doi: 10.2214/AJR.16.16403. Epub 2016 Nov 29. Ultrasound Evaluation of Morton Neuroma Before and After Laser Therapy. Gimber LH1, Melville DM1, Bocian DA2, Krupinski EA3, Guidice MP1, Taljanovic MS1

21) J Photochem Photobiol B. 2016 Nov;164:36-42. Doi.10.1016/j.jphotobiol.2016.08.025. Epub 2016 Aug 31. Use of low level laser therapy to control neuropathic pain: A systematic review. de Andrade AL1, Bossini PS2, Parizotto NA3

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